Our clinical trials of tildacerfont in adults with classic CAH, CAHmelia 203 and CAHmelia 204, are open for screening | LEARN MORE

Our Company

Spruce is a late-stage biopharmaceutical company focused on developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need.

Our wholly-owned product candidate, tildacerfont, is a CRF1 receptor antagonist currently in late-stage trials in adult patients with classic congenital adrenal hyperplasia (CAH), with a planned Phase 2 trial in pediatric classic CAH. We aim to advance the treatment paradigm for classic CAH with a well-tolerated, non-steroidal approach designed to offer markedly improved disease control and reduced steroid burden for patients.

Tildacerfont may also benefit patients with other disorders characterized by elevated levels of or hyperresponsiveness to adrenocorticotropic hormone (ACTH), a hormone involved in the production of cortisol, including a rare form of polycystic ovary syndrome (PCOS).

Partnering with Spruce

Spruce is dedicated to developing and commercializing novel therapies for rare endocrine disorders with significant unmet medical need. We welcome discussion on strategic collaboration opportunities with companies that share our mission to advance novel therapies for patients impacted by rare endocrine disorders. For additional information, please contact us at partnering@nullsprucebiosciences.com.

Contact Us

Spruce Biosciences, Inc.

2001 Junipero Serra Boulevard
Suite 640
Daly City, California 94014 USA

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