Our clinical trials of tildacerfont in adults with classic CAH, CAHmelia 203 and CAHmelia 204, are open for screening | LEARN MORE


At Spruce, we are dedicated to finding new ways to treat rare endocrine disorders. Our team is focused on advancing the development of novel therapies that improve outcomes for people with classic congenital adrenal hyperplasia (CAH), and other rare endocrine disorders. We are led by seasoned life sciences professionals who have significant experience in developing and commercializing orphan drug therapies.

With tildacerfont, we aim to advance the treatment paradigm for classic CAH patients with a non-steroidal approach designed to offer improved disease control and reduced glucocorticoid steroid burden in patients. To learn more about CAH, click here.

We are currently conducting clinical trials evaluating tildacerfont for the treatment of adults with classic CAH. We plan to initiate a Phase 2 trial in pediatric classic CAH patients in 2021.

Patients, above all else

As an innovative late-stage company, our efforts are built around the needs of patients and their loved ones. We approach our work every day with the goal of improving health outcomes and easing the disease burden for patients with rare endocrine disorders.

We listen intently to what the patient community tells us about living with conditions such as CAH, and aim to address these needs in our development programs. We have adapted our clinical trial programs to ensure the utmost safety and flexibility for participants as well as caregivers in the era of COVID-19.

To learn more about Spruce advocacy or to ask us a question, we invite patient and family caregiver advocates to connect with us at advocacy@nullsprucebiosciences.com.

Patient Advocacy
at Spruce

Spruce values our collaborative partnerships with the patient advocacy community. To ensure that these collaborations respect the independence of all partners and are built on integrity and trust, we align with the Bio Industry Organization’s guiding principles. These principles represent the highest industry standards for interactions with patient groups.

We amplify efforts to bring awareness to the needs of those who live with or care for someone with CAH. Spruce acknowledges the following organizations and we encourage you to visit their websites:

The Magic Foundation
National Adrenal Diseases Foundation

For additional information about CAH, please visit these sites: